Giotto’s most celebrated altarpiece is the “Ognissanti Madonna” which once sat on the high altar of the Florentine church of the Ognissanti. Working against the Byzantine conventions of the day, Giotto was able to create an image of Mary enthroned that is both naturalistic and majestic. This lecture will examine Giotto painting and compare it to two other contemporary altarpieces by Cimabue and Duccio which sit in the same room of the Uffizi Galleries.