There are hundreds of saints associated with the bubonic plague and even more if we include the other epidemic diseases that ravaged Europe in the Middle Ages and Early Modern Period. In this lecture we will take a deep dive into the stories and iconography of the saints appealed to for relief from the Black Death such as St. Roch and St. Sebastian. Other less well-known plague saints will also get their turn in the spotlight. We will then consider the saints associated with other epidemic diseases of this time such as ergotism (St. Anthony’s Fire), smallpox, and leprosy. As always, we will explore these saints and these diseases through the lens of religious iconography and art and draw connections between the understanding of illness in the past with the current state of medical knowledge.